Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

R Mansoor; RJ Commons; NM Douglas; B Abuaku; J Achan; I Adam; GO Adjei; M Adjuik; BH Alemayehu; R Allan; EN Allen; AR Anvikar; E Arinaitwe; EA Ashley; H Ashurst; PBS Asih; N Bakyaita; H Barennes; KI Barnes; L Basco; Q Bassat; E Baudin; DJ Bell; D Bethell; A Bjorkman; C Boulton; T Bousema; P Brasseur; H Bukirwa; R Burrow; VI Carrara; M Cot; U D’Alessandro; D Das; S Das; TME Davis; M Desai; AA Djimde; AM Dondorp; G Dorsey; CJ Drakeley; S Duparc; E Espié; JF Etard; C Falade; JF Faucher; S Filler; C Fogg; M Fukuda; O Gaye; B Genton; A Ghulam Rahim; J Gilayeneh; R Gonzalez; RF Grais; F Grandesso; B Greenwood; A Grivoyannis; C Hatz; EM Hodel; GS Humphreys; J Hwang; D Ishengoma; E Juma; SP Kachur; PA Kager; E Kamugisha; MR Kamya; C Karema; K Kayentao; A Kazienga; JR Kiechel; PE Kofoed; K Koram; PG Kremsner; DG Lalloo; M Laman; SJ Lee; B Lell; AW Maiga; A Mårtensson; M Mayxay; W Mbacham; R McGready; H Menan; D Ménard; F Mockenhaupt; BR Moore; O Müller; A Nahum; JL Ndiaye; PN Newton; BE Ngasala; F Nikiema; AM Nji; H Noedl; F Nosten; BR Ogutu; O Ojurongbe; L Osorio

Journal article

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

R Mansoor, RJ Commons, NM Douglas, B Abuaku, J Achan, I Adam, GO Adjei, M Adjuik, BH Alemayehu, R Allan, EN Allen, AR Anvikar, E Arinaitwe, EA Ashley, H Ashurst, PBS Asih, N Bakyaita, H Barennes, KI Barnes, L Basco Show all

BMC Medicine | Published : 2022

DOI: 10.1186/s12916-022-02265-9

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Abstract

Background: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods: Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the ..

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Julie Simpson Author

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Funding Acknowledgements

RJC is funded by an Australian National Health and Medical Research (NHMRC) Emerging Leader Investigator Grant (1194702). RNP is a Wellcome Trust Senior Fellow in Clinical Science (200909). JAS is funded by an Australian NHMRC Senior Research Fellowship 1104975. NJW is a Wellcome Trust Principal Fellow. WWARN is funded by Bill and Melinda Gates Foundation and Exxon Mobil Foundation grants. The funders of the study had no role in study design, data collection, data analysis, data interpretation or writing of the paper. The corresponding authors had full access to all the data in the study and had final responsibility for the decision to submit for publication.